DiagCor’s patented flow-through hybridization technology makes it faster, easier and more economical to analyse DNA and RNA samples. Flow-through assays also offer excellent sensitivity and specificity.
We offer stand-alone hybridization solutions and complete MDx systems with associated services and support.
The DiagCor range of cost-effective genetic test kits includes common medical and food applications. We have more MDx tests in our product pipeline – subscribe to MDX Newsletter to learn about them.
Analysis of nucleic acid is generally available in three resolutions:
DiagCor’s specialist technology and simple lab protocols excel at producing accurate medium-resolution analyses of various types of genetic material. We also offer low-resolution solutions.
DiagCor’s patented flow-through hybridization technology and simple lab protocols delivers easy-to-read results.
We greatly reduce the time and cost of medium-resolution DNA analysis and make genetic testing available to more people than ever.
DNA hybridization is key to the practical, cost-effective identification of specific genetic material.
DiagCor’s patented flow-through hybridization technology works by binding assay and amplicons via a vacuum process.
The presence of target molecules are displayed in a binary format on a nitrocellulose membrane for instant identification.
The technology means hybridization no longer takes hours.
Flow-through hybridization avoids the inefficiency of shaking by channelling the target molecule towards the probes by applying suction via a vacuum. This unique process directs the amplicons towards the DNA probes to form duplexes.
The invention of flow-through changed the hybridization process from passive channeling to active channeling, allowing the recombination reactions to complete in seconds. This delivers many advantages:
Conventional hybridization requires assays to be shaken for many hours to obtain a result.
Flow-through hybridization delivers a result in as little as 35 minutes. Multiple tests can be conducted simultaneously. Automating the process makes it even faster.
Conventional hybridization delivers low resolution results in an analogue form characterized by high noise. Attempting to increase the sensitivity of this method often reduces the specificity of the test.
Flow-through hybridization is highly sensitive with an excellent signal-to-noise ratio. The high specificity of the process enables more genetic types to be accurately identified with a single test.
Conventional hybridization typically produces difficult-to-analyse low resolution blotting. Without considerable experience, results are often misread.
Flow-through hybridization delivers medium resolution results in a simple binary format that can be read instantly with little training.
Conventional hybridization typically provides only one reliable test result. Attempting to obtain more results often means more false positives.
Flow-through hybridization enables the unambiguous detection of multiple pathogens and genotypes to be identified accurately in a single reaction.
Conventional hybridization is less efficient therefore less productive.
Flow-through hybridization increases lab output. Test kits are readily available for many common conditions and applications. Different tests can be applied on a single MDx platform. The range of compatible test kits continues to expand.
Conventional hybridization is more expensive when every factor is considered.
Flow-through hybridization is more efficient, faster and requires less training. It all adds up to a lower total cost of ownership.
Comparison of flow-through hybridization with other hybridization methods
DiagCor’s founder and chairman, Dr Joseph W.O. Tam, is the original inventor of the fundamental method of Flow-through hybridization, developed during his appointment as an Associate Professor in the University of Hong Kong.
The invention provides a wide range of diagnostic and screening methods, as well as devices upon which these method are carried out; and DiagCor holds patents relating to its proprietary Flow-through hybridization system: